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19 results

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Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model.
Luo R, Su LY, Li G, Yang J, Liu Q, Yang LX, Zhang DF, Zhou H, Xu M, Fan Y, Li J, Yao YG. Luo R, et al. Autophagy. 2020 Jan;16(1):52-69. doi: 10.1080/15548627.2019.1596488. Epub 2019 Apr 6. Autophagy. 2020. PMID: 30898012 Free PMC article.
Food and Drug Administration; FKBP5: FK506 binding protein 5; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; gemfibrozil: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid; GFAP: glial fibrillary acidic protein; GLI2/THP1: GLI family zinc finger 2; HM: human microglia; IL6: in …
Food and Drug Administration; FKBP5: FK506 binding protein 5; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; gemfibrozil: 5-(2,5-dimethylp …
Adverse effects of SYP-3343 on zebrafish development via ROS-mediated mitochondrial dysfunction.
Chen G, Wang M, Zhu P, Wang G, Hu T. Chen G, et al. J Hazard Mater. 2022 Sep 5;437:129382. doi: 10.1016/j.jhazmat.2022.129382. Epub 2022 Jun 17. J Hazard Mater. 2022. PMID: 35749898
Nevertheless, the developmental toxicity and potential mechanism of SYP-3343 have not been well-documented. The results showed that SYP-3343 was relatively stable and maintained within the range of 20 % in 24 h, and the LC(50) value to embryos at 72 hpf was 17.13 mu …
Nevertheless, the developmental toxicity and potential mechanism of SYP-3343 have not been well-documented. The results showed that …
SYP-3343 drives abnormal vascularization in zebrafish through regulating endothelial cell behavior.
Chen G, Liu J, Wang H, Wang M, Wang G, Hu T. Chen G, et al. Food Chem Toxicol. 2023 Apr;174:113671. doi: 10.1016/j.fct.2023.113671. Epub 2023 Feb 14. Food Chem Toxicol. 2023. PMID: 36796616
SYP-3343 is a novel strobilurin fungicide with excellent and broad-spectrum antifungal activity, and its potential toxicity raises public health concerns. However, the vascular toxicity of SYP-3343 to zebrafish embryos is still not well understood. In the present st …
SYP-3343 is a novel strobilurin fungicide with excellent and broad-spectrum antifungal activity, and its potential toxicity raises pu …
Integrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer's Disease.
Lei X, Xu H, Wang Y, Gao H, Zhao D, Zhang J, Zhu Z, Zuo K, Liu Y, Li X, Zhang N. Lei X, et al. Drug Des Devel Ther. 2023 Sep 14;17:2841-2858. doi: 10.2147/DDDT.S402624. eCollection 2023. Drug Des Devel Ther. 2023. PMID: 37727255 Free PMC article.
Moreover, the levels of TNF-alpha, IL-1beta, and IL-18 in the brain hippocampus of mice were determined by ELISA. The expression of Bax, Bcl-2, Caspase-1, PSD95, SYP, ICAM-1 and MCP-1 proteins in the hippocampus was detected by Western blotting. Furthermore, qRT-PCR was us …
Moreover, the levels of TNF-alpha, IL-1beta, and IL-18 in the brain hippocampus of mice were determined by ELISA. The expression of Bax, Bcl …
Identification of novel synaptonemal complex components in C. elegans.
Hurlock ME, Čavka I, Kursel LE, Haversat J, Wooten M, Nizami Z, Turniansky R, Hoess P, Ries J, Gall JG, Rog O, Köhler S, Kim Y. Hurlock ME, et al. J Cell Biol. 2020 May 4;219(5):e201910043. doi: 10.1083/jcb.201910043. J Cell Biol. 2020. PMID: 32211899 Free PMC article.
Here we report the biochemical identification of two new SC components, SYP-5 and SYP-6, in Caenorhabditis elegans. SYP-5 and SYP-6 are paralogous to each other and play redundant roles in synapsis, providing an explanation for why these genes have eva …
Here we report the biochemical identification of two new SC components, SYP-5 and SYP-6, in Caenorhabditis elegans. SYP …
The effect of ixekizumab on axial manifestations in patients with psoriatic arthritis from two phase III clinical trials: SPIRIT-P1 and SPIRIT-P2.
Deodhar A, Gladman D, Bolce R, Sandoval D, Park SY, Leage SL, Nash P, Poddubnyy D. Deodhar A, et al. Ther Adv Musculoskelet Dis. 2023 Aug 24;15:1759720X231189005. doi: 10.1177/1759720X231189005. eCollection 2023. Ther Adv Musculoskelet Dis. 2023. PMID: 37645684 Free PMC article.
BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory condition predominantly affecting the peripheral joints. However, some patients with PsA can experience axial involvement which is manifested with back pain and associated with increased burden of illness. ... …
BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory condition predominantly affecting the peripheral joints. However, som …
Effectiveness of deep cervical fascial manipulation and yoga postures on pain, function, and oculomotor control in patients with mechanical neck pain: study protocol of a pragmatic, parallel-group, randomized, controlled trial.
Raja G P, Bhat N S, Fernández-de-Las-Peñas C, Gangavelli R, Davis F, Shankar R, Prabhu A. Raja G P, et al. Trials. 2021 Aug 28;22(1):574. doi: 10.1186/s13063-021-05533-w. Trials. 2021. PMID: 34454582 Free PMC article.
INTRODUCTION: Mechanical neck pain (MNP) is a commonly occurring musculoskeletal condition that is usually managed using electrical modalities, joint mobilization techniques, and therapeutic exercises, but has limited evidence of their efficacy. ...The purpose of this stud …
INTRODUCTION: Mechanical neck pain (MNP) is a commonly occurring musculoskeletal condition that is usually managed using electrical modaliti …
α-Pyrones, secondary metabolites from fungus Cephalotrichum microsporum and their bioactivities.
Zhu H, Li D, Yan Q, An Y, Huo X, Zhang T, Zhang M, Wang C, Xia M, Ma X, Zhang Y. Zhu H, et al. Bioorg Chem. 2019 Mar;83:129-134. doi: 10.1016/j.bioorg.2018.10.022. Epub 2018 Oct 17. Bioorg Chem. 2019. PMID: 30352358
Cephalotrichum microsporum (SYP-F 7763) was a fungus isolated from the rhizosphere soil of traditional Chinese medicine Panax notoginseng. ...
Cephalotrichum microsporum (SYP-F 7763) was a fungus isolated from the rhizosphere soil of traditional Chinese medicine Panax notogin …
Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment.
Liu Y, Zhang X, Yan D, Wang Y, Wang N, Liu Y, Tan A, Chen X, Yan H. Liu Y, et al. Toxicol Appl Pharmacol. 2020 Apr 15;393:114949. doi: 10.1016/j.taap.2020.114949. Epub 2020 Mar 5. Toxicol Appl Pharmacol. 2020. PMID: 32147541
Chronic exposure to ACR caused gait abnormality and cognitive dysfunction, which was associated with neuronal lesions, decrease in synapse associated proteins including synapsin I (SYN1), synaptophysin (SYP) and postsynaptic density protein 95 (PSD95), neurogenesis suppres …
Chronic exposure to ACR caused gait abnormality and cognitive dysfunction, which was associated with neuronal lesions, decrease in synapse a …
Bombesin attenuated ischemia-induced spatial cognitive and synaptic plasticity impairment associated with oxidative damage.
Yao Y, Wang F, Yang X, Zang D, Yang J, Wang Z. Yao Y, et al. Biomed Pharmacother. 2018 Jul;103:87-93. doi: 10.1016/j.biopha.2018.03.155. Epub 2018 Apr 7. Biomed Pharmacother. 2018. PMID: 29635132
Besides, the decreased expression of synapse plasticity-related proteins, calcium- calmodulin- dependent protein kinase II (CaMKII) and synaptophysin (SYP) in the hippocampus were increased with drug treatment. In conclusion, bombesin could protect the oxidative stress and …
Besides, the decreased expression of synapse plasticity-related proteins, calcium- calmodulin- dependent protein kinase II (CaMKII) and syna …
19 results